Apparently I'm not very defensive-minded. I do make sure all of the doors and windows are locked, most all day and certainly all night. The only door that is ever unlocked is the door between house and garage, and I keep the garage door closed and have just recently managed to convince my wife that the car sitting in the driveway must be locked because it has a garage door opener between the front seats. That battle has taken years.
As for weapons, all of my rifles and shotguns are locked in the gun cabinet and my handgun is generally in my bedside gun safe. The safe is has an electronic combination lock which I can open in the dark, half-asleep, in less than a second. I have an "alarm" (my wife) that wakes me for every noise in the house, no matter how small, so I'm pretty confident that I'd have time to get my weapon in the event of a burglary. I sometimes wear the gun on my hip during the day, but mostly only when I go out and don't bother taking it off when I get home. Since I work at home, there are many days I never leave the house.
Honestly, I don't worry much about my things. If a burglar wants to come take my stuff, I'll help him carry it out (not really, but you get the idea). My concern is for my family's safety.
All but one of my kids' rooms are near mine, on the second floor, so anyone that comes in will have to come in at ground level, then find the stairs and come up before he can get to us. The one exception is my daughter, who has a room in the basement. Her door is locked at night, and there's a grille (bolted to concrete) covering the inside of her window which she can unlatch and open but protects her from exterior entry. Her instructions in the event of any kind of alarm are to go out her window and run to the neighbors' house.
I've been less concerned about security because I live in a very safe neighborhood (based on the non-history of invasions) and I'm one of the less attractive targets. My house is nice, but I'm a block away from a hundred homes in the $400-$600K range.
However, I'm about to move to an isolated house out in the sticks (nearest neighbor is about a half mile away), and although perception is that it's a very safe area, where people don't lock their doors, statistics show that it's actually more violent, per-capita, than Ogden. My house will also be the most attractive target in 10 miles, in terms of monetary value.
Since we're designing the house ourselves, I'm working with the architect to make it defensible. I'm focused on defending the people, not so much the stuff. I'm going to put all of the bedrooms on the second floor (with rope ladders for window escape in the event of a fire) and put a steel-cored door in a steel frame at the base or top of the stairs. My wife insists that it open into a recess so that it's out of the way when open, and the architect says that's easy to do.
I'll put security laminate on all of the windows, and I'll probably add an alarm system. I plan to put the dog kennel/run close to the house and that's pretty good alarm, too. I'll put motion-activated exterior lighting around the house and yard.
I'll also put motion-activated lights in the common areas of the house and I'm considering cameras as well, with the feeds going to a computer so I can access the imagery from my laptop (which, unlike my gun, is always within reach). If it's not too expensive (probably will be), I might get locks that I can lock and unlock remotely, ideally through computer control. There will definitely be a camera or two on the porch, and an intercom so strangers can be questioned without opening the door.
As for weapons, as long as I have kids in the house the guns will all be locked up. I might put a small gun safe similar to the one I have now near front door so that I can easily grab a gun before opening the door to a stranger, and I'll continue keeping one by my bed.
My main approach to home defense, though, is going to be keeping bad guys out. If you shoot someone they bleed all over your carpet.