Can you reword the question? Does Yes mean safety on or safety off?
My gun (XD) has a grip and a trigger safety, but I assume these don't count, so I answered "Mine does not have one".
I think the key is to always carry and handle your gun in the same configuration. Whether the safety is on or off isn't going to make a big difference. But trying to shoot a gun when you think the safety is off can be bad, and shooting a gun when you think the safety is on is even worse.