My wife finally settled on the Kel-Tec P3AT. We agreed that since she was not interested in drawing-down on a BG at a distance in a mall-shoot-up situation and was really just interested in SELF-defense at close-ranges, she really didn't NEED more firepower than that and her inability to conceal much more than that made packing something larger fairly impractical.
My wife is in corporate sales and wears fairly well-fitting business clothes. Mostly slacks but occasionally a skirt.
So she purchased a Galco ankle-holster for slacks/jeans days (90% of the time) that she loves so much I'm considering trying one with my gun.
She also is getting a Thigh Holster for dress/skirt days.
She also has a cheap Uncle Mike's IWB for random other days that either holster for whatever reason doesn't work (but she usually uses it as pocket-carry not IWB).
She likes her P3AT quite a bit for it's size. She only shoots a box of ammo every time we hit the range, though, b/c it DOES hurt her hand after a few rounds. For better target practice she then resorts to shooting my 9.
Hope that helps! The P3AT is also pretty affordable, as is the ammo.